Wednesday, December 3, 2008

Picornaviridae & Orthomyxoviridae

Cold – Picornaviridae
Influenza – Orthomyxoviridae



Though picornaviruses are named for their small (“pico” + “RNA” = picorna) size, they include a large and diverse array of viruses – over 200 serotypes. These viruses can be traced all the way back to Ancient Egyptian records of polio epidemics, but are still around and cause a menagerie of diseases today, from polio to hepatitis A to the “common cold.”

· Picornaviruses contain positive sense, single-stranded RNA that is approximately 7-8 kilobases long.
· The genome is monopartite and polyadenylated at the 3’ end, but has a VPg protein at the 5’ end in place of a cap.
· The viral RNA is infectious and replication takes place in the cytoplasm.
· The virus has an IRES (Internal Ribosomal Entry Site) which distinguishes it from many other RNA viruses.
· The virus is naked with an icosahedral capsid.
· The capsid is one of the smallest of all viruses with a diameter of only 27-30nm.
Picture of picornaviridae


Control
- wash hands
- do not sneeze anywhere other than a tissue or handkerchief
- avoid people with cold
- stay home and rest well if you’re down with flu or cold

Do you know?

It is not possible to be immune to cold or flu as they have many different serotypes circulating simultaneously... And a large amount of virus is present in nasal discharge.

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