Herpesviridae

Any one knows that Herpesviridae are a large virus family that affect animal and human?
Herpesviruses all share a common structure—all herpesviruses are composed of relatively large double-stranded, linear DNA genomes encoding 100-200 genes encased within an icosahedral protein cage called the capsid which is itself wrapped in a lipid bilayer membrane called the envelope. Herpesvirus is unique because after primary infection virus normally remain latent , reactivation occur when (stress,expose to sunlight during menstrual period)
Virus hide in the nerves tissue. Causes viralencephalitis or if passed from mother
birth, may cause brain damage in the child.
Herpesvirus genome has a concentric virion which contain
-Inner core
-Icosahedral capsid
-Amorphous tegument
-Envelope (glycoprotein)

Pathogenesis

Herpes simplex viruses

-HSV1 (cold sores) –oral cavity

-HSV2 (genital herpes) -genital

Varicella Zoster virus
-Varicella (chicken pox) –respiratory tract, pharynx

- Herpes zoster (shingles)

-Cytomegalovirus –? Virus found in saliva, urine, semen,
cervial secretion, breast milk

-EBV –nasopharynx, salivary gland
Clinical Features

Cold sores -blisters around the mouth -1 week

-Also affect eyes, gum.

-Genital herpes -blisters, burning sensation, discharge -1 -3 weeks

-Fever

-Lesion all over body

-Scratched lesion lead to secondary infection!

-Scarring

-Dangerous in pregnant women!

-May affect nervous system